Is Differin helpful for Melasma? can Differin cause Melasma? Differin is mentioned in 44 posts about Melasma. - Page 2 In a randomized clinical trial, the efficacy of adapalene gel 0.1% was found to be comparable to that of tretinoin 0.05% cream in the treatment of melasma and solar lentigines, but patients using. 💜Sunscreens for darks spots/melasma La Roche Posay antihelios mineral MDSolar Sciences Mineral Tinted Then he put me on differin cream+hydroquione+locoid cream then I started getting breakout non stop until now. The Melasma whiten a little bit but the acne gone really worst. 💜Products used Differin gel MD complete darks spot corrector Attitude hand soap Melasma is reported only by a few people who take Differin. We study 1,501 people who have side effects while taking Differin from FDA. Among them, 2 have Melasma. Find out below who they are, when they have Melasma and more. When I started using Differin for acne is when my melasma came out. Before that I had the slightest browning above my lip. Differin worked so well on my acne and I swear it helped w/ anti-aging so I stayed w/ it. Tretinoin cream (Retin A, Renova, Retin A Micro) is a non-hydroquinone cream used to treat melasma. Most often, tretinoin is used in combination with other creams like azelaic acid or hydroquinone. Mild localized side effects are fairly common and include peeling, dry skin, and irritation. Overall, melasma may respond slower to treatment with tretinoin alone than with hydroquinone. Galderma brands include Epiduo® Forte Gel, Mirvaso® Gel, Soolantra® Cream, Differin® Gel, Oracea® Capsules, Dysport® Gel, Restylane®, Sculptra®, Cetaphil® and Proactiv® (to view these brands, click here).